£24.00
A1‑Antitrypsin is a glycoprotein consisting of a polypeptide chain to which 3 oligosaccharide chains are bonded (54000 daltons). It is synthesized in hepatocytes. A1‑Antitrypsin is quantitatively the most important proteinase inhibitor (Pi) in serum and plasma.
Acute hereditary α1-antitrypsin deficiency is suspected in cases of neonatal hepatitis accompanied by progressive liver cirrhosis in early childhood. It is also suspected when severe pulmonary emphysema occurs in adults due to the prevalence of leukocyte elastase, which can lead to unrestrained proteolytic degradation of the pulmonary parenchymal cells.
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